Angiopoietin signalling is a central axis of amyloid-driven vascular dysfunction in Alzheimer's disease

Flotho, M.^, Yang, A.^, Kern, F., Graf, S., Diks, I.F., Shin, H., Berdnik, D., Agam, M., Channappa, D., Shi, S.M., Belnap, M.A., Simmons, E., Bradshaw, K., Grandke, F., Bennett, D.A., Buckwalter, M., Keller, A.*, Wyss-Coray, T.* (2025). biorxiv. doi.org/10.1101/2025.08.25.672093

Luminal Cerebrovascular Proteomics

Shi, S.M.*, Bertozzi, C.R., Wyss-Coray, T. (2025). Bio-protocol 15(15): e5411. doi.org/10.21769/BioProtoc.5411

Isolation and Imaging of Microvessels From Brain Tissue

Buff, J.B., Bertozzi, C.R., Wyss-Coray, T., Shi, S.M.* (2025). Bio-protocol 15(15): e5410. doi.org/10.21769/BioProtoc.5410

Cell-surface proteomic profiling identifies CD72 as a regulator of microglial tiling

Chan, T., Rastogi, M., Williams, M.X., Zhang, S., Shi, S.M., Shuken, S.R., Bartling, T., Wild, K., Atkins, M., Hahn, O., Atkins, Paulo, J.A., Jereb, S., Shuster, A., Yoo, Y., Napole, A., Hernandez, V.G., Luo, L., Buckwalter, M.S., Stevens, B., Deverman, B.E., Kronenberg-Versteeg, D., Gygi, S.P., Wyss-Coray, T., Wernig, W.* (2025). biorxiv. doi.org/10.1101/2025.06.02.657480

Sophia Shi: Decoding the role of sugar molecules in brain aging and neurodegenerative diseases

Shi, S.M.* (2025). Brain Medicine. doi.org/10.61373/bm025k.0074

Glycocalyx dysregulation impairs blood-brain barrier in aging and disease

Shi, S.M., Suh, R.J., Shon, D.J., Garcia, F.J., Buff, J.K., Atkins, M., Li, L., Lu, N., Sun, B., Luo, J., McNerney, M.W., Heiman, M., Bertozzi, C.R.*, Wyss-Coray, T.* (2025). Nature 639, 985–994. doi.org/10.1038/s41586-025-08589-9

• Interviewed on BBC Radio & CBC Radio; Featured in C&EN, Stanford Report, Nature News, Nature Neuroscience Highlights, Newsweek en Español

Synaptic proteins that aggregate and degrade slower with aging accumulate in microglia

Guldner, I.H., Wagner, V.P., Moran-Losada, P., Shi, S.M., Chen, K., Meese, B.T., Oh, H., Guen, Y.L, Lu, N., Wong, P.S., To, N-S., Garceau, D., Guo, Z., Luo, J., Sasner, M., Keller, A., Yang, A.C., Cheung, T., Wyss-Coray, T.* (2025) biorxiv. doi.org/10.1101/2025.05.20.654652

Circulatory proteins shape microglia state and boost phagocytosis

Lu, N., Moran-Losada, P.^, Hahn, O.^, Saksena, A., Tapp, E., Chadarevian, J.P., Dong, W., Shi, S.M., Shuken, S.R., Guldner, I., Zeng, W., To, N., Wong, P.S, Hasselmann, J., Davtyan, H., Sun, J., Li, L., Luo, J., Yang, A.C., Li, Q., Cheung, T.H., Abu-Ramaileh, M., Blurton-Jones, M., Wyss-Coray, T. (2024) biorxiv. doi.org/10.1101/2024.09.30.615861

Unraveling protein dynamics to understand the brain – the next molecular frontier.

Brewer K.D.^, Shi S.M.^ & Wyss-Coray, T.* (2022). Mol Neurodegener. 17, 45. doi.org/10.1186/s13024-022-00546-8

Lipid-based, protein-based, and steric interactions synergize transmembrane signaling stimulated by antigen-clustering of IgE receptors

Bag, N., Wagenknecht-Wiesner, A., Lee, A., Shi, S.M., Holowka, A.D., Baird, B.A.* (2021). Proc Natl Acad Sci USA 118(35). doi.org/10.1073/pnas.2026583118